Which cells would exhibit the greatest radiation effects according to Bergonie and Tribondeau?

Which cells would exhibit the greatest radiation effects according to Bergonie and Tribondeau?

• A. Neurons
• B. Cells with greatest reproductive activity and longest mitotic phases
• C. Mature bone cells
• D. Highly differentiated cells

Answer: (B)

Radiosensitivity rises with how actively a cell divides and how undifferentiated it is. Bergonie and Tribondeau showed that cells with high reproductive activity and a long potential to divide (mitotic future) are most susceptible to radiation damage. The description of cells with the greatest reproductive activity and the longest mitotic phases fits this pattern, so they would show the greatest radiation effects. Neurons are largely non-dividing and highly differentiated, so they’re relatively resistant. Mature bone cells are differentiated and not rapidly dividing, also reducing sensitivity. Highly differentiated cells in general have lower radiosensitivity than actively dividing, less differentiated cells.

Radiosensitivity rises with how actively a cell divides and how undifferentiated it is. Bergonie and Tribondeau showed that cells with high reproductive activity and a long potential to divide (mitotic future) are most susceptible to radiation damage. The description of cells with the greatest reproductive activity and the longest mitotic phases fits this pattern, so they would show the greatest radiation effects.

Neurons are largely non-dividing and highly differentiated, so they’re relatively resistant. Mature bone cells are differentiated and not rapidly dividing, also reducing sensitivity. Highly differentiated cells in general have lower radiosensitivity than actively dividing, less differentiated cells.